The sites first noticed and most complained about during the manifestation stage of the ageing process are the hands, face, knees, elbows, and, particularly in women, the cleavage area. These changes are not associated with ageing alone but also with subcutaneous soft tissue loss and variations in bone structure. A better understanding of the ageing process helps physicians assess age-related changes and plan individually tailored treatment options.

Filler applications have been developed to be able to eliminate skin problems. The primary purpose of the filler applications, which are performed by subcutaneous injection and replace the substances that are reduced with time, is to fill the areas of volume loss in the face. Filler applications may be preferred to help reduce the visible appearance of perioral lines, nasolabial grooves and volume loss in the cheek area. The degree of change that can be achieved varies according to the individual's tissue characteristics and the product used.

Filler applications are used for the following processes:
• Lifting the eyebrows
• Plump up the lips
• Correcting the asymmetries in the face
• Emphasizing the cheeks
• Reducing lines and wrinkles
• Correcting the hollowness of the temporal area
• Lifting the corners of the lips
• Resolve the under-eye volume problems
• Correcting nasal height problems
• Removing the dents occurred after rhinoplasty
• Getting rid of eye contour wrinkles and under-eye bags